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For patients with higher BMIs or more severe insulin resistance (Type 2 Diabetes), Tirzepatides dual mechanism often breaks through metabolic walls that Semaglutide cant quite scale

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Diabetes 63(12):41864196 van Bloemendaal L, Veltman DJ, ten Kulve JS, Groot PF, Ruh HG, Barkhof F, Sloan JH, Diamant M, IJzerman RG (2015) Brain reward-system activation in response to anticipation and consumption of palatable food is altered by glucagonlike peptide1 receptor activation in humans